The more one reads about how brain works, the more one realizes how shallow we know about our brain. It sounds like a philosophical paradox that we believe our brain has the unlimited potential to understand how itself works, unlimitedly.

The first big question is still the map, a connection map of the brain. It does not only have anatomical meaning. It should be a functional map of how information flows through the nervous system. There should be principles of how the wiring develops and changes.

The second big question is the principle of computation. Does the computation of all nervous system has a simple principle as beautiful as "central dogma" so that the difference of our brain and the brain of a fly only a difference of connection organization. Or there is different modules of computations happens in different brains. It is more like a belief rather than models. I believe neuronal computation has a central dogma even if I do not know anything about it. I believe having the map is very urgent.